Bipolar Research Today is a free monthly online journal that collates and summarizes the latest research about Bipolar, including details on bipolar disorder, symptoms, treatment, depression, medication.

Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain.

Machado-Vieira R, Schmidt AP, Avila TT, Kapczinski F, Soares JC, Souza DO, Portela LV

Mood Disorders Program, HMIPV, Fundação Faculdade Federal de Ciências Medicas de Porto Alegre, RS, Brasil.

Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold increase in crossing responses in the open field test and increased 30% the cerebrospinal fluid concentration of S100B, as compared to vehicle group. Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania.

Published 7 December 2004 in Life Sci, 76(7): 805-11.
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