Bipolar Research Today is a free monthly online journal that collates and summarizes the latest research about Bipolar, including details on bipolar disorder, symptoms, treatment, depression, medication.

An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.

Halstead JR, Jalink K, Divecha N

Department of Cellular Biochemistry, the Netherlands Cancer Institute, AvL ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.halstead@nki.nl

Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.

Published 21 November 2005 in Trends Pharmacol Sci, 26(12): 654-60.
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