Bipolar Research Today is a free monthly online journal that collates and summarizes the latest research about Bipolar, including details on bipolar disorder, symptoms, treatment, depression, medication.

Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.

Schosser A, Fuchs K, Scharl T, Leisch F, Bailer U, Kasper S, Sieghart W, Hornik K, Aschauer HN

Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria. alexandra.schosser@meduniwien.ac.at

After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

Published 2 April 2007 in Eur Neuropsychopharmacol, 17(6): 501-5.
Full-text of this article is available online (may require subscription).

© 2004-2008 Bipolar Research Today. All Rights Reserved.