Bipolar Research Today is a free monthly online journal that collates and summarizes the latest research about Bipolar, including details on bipolar disorder, symptoms, treatment, depression, medication.

Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder.

Dean B, Digney A, Sundram S, Thomas E, Scarr E

The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia. bdean_mhri@iprimus.com.au

We have shown that plasma apolipoprotein E is significantly decreased in treatment-free subjects with schizophrenia spectrum and bipolar disorder but increases after treatment in bipolar disorder. Levels of apolipoprotein D were not changed by treatment. Hence changed apolipoprotein E could be involved in abnormalities in lipid homeostasis in some subjects with psychiatric diseases.

Published 3 March 2008 in Psychiatry Res, 158(1): 75-8.
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