Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.
Zhao Q, Che R, Zhang Z, Wang P, Li J, Li Y, Huang K, Tang W, Feng G, Lindpaintner K, He L, Shi Y
Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China.
In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.
Published 11 June 2010 in Psychiatry Res.
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